31 - Target-site resistance kdr genotypes affect temperature dependent toxicity of pyrethroids of Aedes aegypti mosquitoes

Tuesday, March 24, 2026

2:25 PM - 2:35 PM PDT

Location: B119

Presenter(s)

KD

Kendra A. Dagg, MSc, MPH

PhD Candidate
University of Florida / US Army, Florida, United States

Co-Author(s)

Al A. Estep, III, n/a

Research Entomologist
USDA-ARS Center for Medical, Agricultural, and Veterinary Entomology, Florida, United States
OB

Oshneil Baker, n/a

University of Florida, Florida, United States
Edmund Norris, Research Chemist

Research Chemist
USDA-ARS, Florida, United States
MF

Muhammad Farooq, n/a

Mosquito Control Engineer
Anastasia Mosquito Control District, Florida, United States
Whitney Qualls, PhD

Assistant Director
Anastasia Mosquito Control District, Florida, United States
EB

Edwin A. Burgess, IV, PhD

Asst. Professor
University of Florida, Florida, United States

Abstract: Temperature affects insecticide toxicity, with many pyrethroids increasing in toxicity as temperature decreases. Here we examined how different knockdown (kdr) mutations in Aedes aegypti affected the temperature-toxicity relationship through three toxicology assays at three temperatures (19°C, 25°C, 31°C). Assays demonstrated temperature affected the efficacy of pyrethroid performance with clear differentiation by kdr mutation. These findings suggest that temperature may interact with kdr mutations in Ae. aegypti emphasizing the complex interactions between genetic mutations and temperature.