22 - Essential Oils Reimagined: A Biologically Based Larvicide for Mosquito Control

Abstract: YEEO Eco-Safe’s environmentally friendly larvicide has been developed using baker’s yeast (Saccharomyces cerevisiae) to encapsulate essential oils for targeted delivery to mosquito larvae. This proprietary yeast-based formulation provides an effective, biodegradable alternative to chemical larvicides, reducing non-target impacts and residue buildup in aquatic habitats, and introducing a novel mode of action against resistant populations. Laboratory, semi-field, and field trials have demonstrated robust and consistent control of Aedes, Culex, and Anopheles species, including insecticide-resistant populations, highlighting its suitability for integration into mosquito abatement programs.

The technology has progressed from academic development to regulatory review in the US and Southeast Asia. Field trials at multiple mosquito abatement districts as part of the US EPA registration process have generated critical data on efficacy and operational performance under real-world conditions. These trials have demonstrated excellent larval control across a wide range of conditions. These studies support product registration and guide best-practice recommendations for operational use. In parallel, new formulations with extended residual activity are being developed using naturally derived matrices to sustain release and reduce reapplication frequency while maintaining the same environmentally responsible mode of action. Early engagement with programs and distributors in Asia and the US has revealed strong interest in sustainable biological alternatives aligned with modern integrated mosquito management approaches.

Our next steps include completing EPA registration in 2026, followed by production and sales in the US, continuing extended-release formulation optimization and testing, and continuing field trials with partners in Asia. Together, these efforts will advance YEEO Eco-Safe’s technology from innovation to implementation, supporting more sustainable and effective mosquito control worldwide.