87 - Addressing Insecticide Resistance in Brazil: Introducing Optica® ULV for Enhanced Vector Control Programs 

Brazilian vector control programs face mounting challenges from widespread resistance to temephos and deltamethrin, compromising effectiveness against Aedes aegypti populations transmitting dengue, Zika, chikungunya, and yellow fever. Optica® ULV Space Spray represents a promising new solution under development, featuring Tenebenal® brand Broflanilide—the first meta-diamide ULV formulation (IRAC Group 30) for public health applications in Brazil, approved by the WHO. This novel mode of action targets GABA-gated chloride channels via previously unexploited synaptic pathways, ensuring no cross-resistance with existing chemical families. 

Field trials across Brazil demonstrated exceptional efficacy against both susceptible and resistant Aedes populations, achieving 100% mortality within 24-48 hours at application rates of 55-110 mL/hectare. The unique "mortal stupor" effect provides visible confirmation of performance, eliminating host-seeking behavior within one hour and preventing disease transmission without the biting frenzy associated with traditional chemistries. 

Upon regulatory approval and market introduction, Optica ULV's ready-to-use formulation will enable seamless integration with existing equipment and protocols, facilitating easy rotation with products like Cielo® ULV. This compatibility will preserve the effectiveness of current vector control tools while providing immediate solutions for resistant populations. WHO prequalification confirms its suitability for global public health programs, positioning it as a critical resistance management tool to restore comprehensive mosquito control capabilities in Brazilian municipalities.